Antengene Presents Latest Preclinical Results of ATG-207 (αCD3-TGF-β Bifunctional Fusion Protein) at ACR 2026
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SHANGHAI and HONG KONG, Nov. 11, 2026 /PRNewswire/ -- Antengene Corporation Limited ("Antengene", SEHK: 6996.HK) , a leading innovative, commercial-stage global biotech company…
SHANGHAI and HONG KONG, Nov. 11, 2026 /PRNewswire/ -- Antengene Corporation Limited ("Antengene", SEHK: 6996.HK) , a leading innovative, commercial-stage global biotech company dedicated to discovering, developing and commercializing first-in-class and/or best-in-class medicines for autoimmune diseases, solid tumors and hematological malignancies indications, today announced that it has presented the latest preclinical results of ATG-207 (αCD3-TGF-β Bifunctional Fusion Protein) in a Poster Presentation at the 2026 American College of Rheumatology (ACR) Annual Meeting.
Title: Preclinical Characterization of ATG-207, a Masked and TGFβRIII-Biased αCD3-TGF-β Fusion Protein, for the Treatment of T Cell-Related Autoimmune DiseasesPoster: #0974Session: Poster Session B, (0965-0976) T Cell Biology & Targets in Autoimmune & Inflammatory Disease Poster B
Conclusion: ATG-207 combines CD3-mediated T cell modulation with TGFβRIII-biased TGF-β signaling to suppress pathogenic T cells while promoting regulatory T cell differentiation. These preclinical findings support receptor-biased, context-restricted TGF-β delivery as a potential strategy for durable immune tolerance restoration in T cell–mediated autoimmune diseases.
Antengene Corporation Limited ("Antengene", SEHK: 6996.HK) is a global, R&D-driven, commercial-stage biotech company focused on developing first-in-class/best-in-class therapeutics for diseases with significant unmet medical needs. Its pipeline spans from preclinical to commercial stages, with key investigational candidates including ATG-022 (CLDN18.2 ADC), ATG-037 (oral CD73 inhibitor), ATG-101 (PD-L1 x 4-1BB bispecific antibody), ATG-125 (B7-H3 × PD-L1 bispecific ADC), ATG-207 (αCD3-TGF-β bifunctional fusion protein), as well as T cell engager (TCE) programs developed using Antengene's proprietary AnTenGager® platform.
AnTenGager®, is Antengene's proprietary TCE 2.0 platform, featuring "2+1" bivalent binding for low expressing targets, steric hindrance masking…
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